Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
The Shoop Shoop Song (It's In His Kiss) — Betty Everett
Opening, at the beauty salon.
One Fine Day (Rerecorded) — The Chiffons
[European version] Opening.
Into the Groove — Madonna
At the dance club, Gary meets Susan; (repeats) End Credits.
Urgent — Junior Walker
Susan robs Bruce in their hotel room while he's sleeping.
You Belong to Me — Carly Simon
Gary and Roberta's house party.
Lust for Life — Iggy Pop
Jimmy's van radio is playing this song as he is saying goodbye to Susan at Battery Park.
Sucker M.C.'s — Run--D.M.C.
Susan freshens up in the women's room at the Port Authority.
Mashed Potato Time — Dee Dee Sharp
One Thing Leads to Another — The Fixx
Gary calls Susan at Crystal's apartment.
Respect — Aretha Franklin
Roberta follows Susan into a clothing boutique and watches her try to steal a pair of boots.
Someday, Someway — Marshall Crenshaw
Dez and Roberta try to order breakfast at a diner before being thrown out.